Dimedrol farm group. Diphenhydramine tablets: instructions for use

Instructions for use:

Diphenhydramine is an antiallergic agent, an H1 receptor blocker.

Release form and composition

Dosage forms of Dimedrol:

• Tablets: white, round flat-cylindrical shape with a chamfer (10 pcs in a blister pack, in a carton pack of 1, 2, 3 or 5 packs; 10 pcs in a non-cell blister pack, in a paper bag 1 pack or in a carton pack 1, 2 or 3 packs, 10 pieces or 20 pieces in dark glass jars, 1 jar in a carton box);
• Solution for intravenous (in / in) and intramuscular (in / m) administration: a colorless transparent liquid in 1 ml ampoules (5 pcs in a blister pack, in a carton pack 1 or 2 packs; 10 pcs in a carton or 10 pcs in a blister pack, 2 packs in a carton pack, 10 pcs in a blister pack, 1 pack in a carton pack).

• Tablets: diphenhydramine hydrochloride, 1 pc. - 50 mg;
• Solution: diphenhydramine, 1 ml - 10 mg.

Auxiliary components:

• Tablets: water-soluble methylcellulose - 0.326 mg; lactose monohydrate (milk sugar) - 75 mg, colloidal silicon dioxide (aerosil) - 0.76 mg, corn starch - 23.154 mg, stearic acid - 0.76 mg;
• Solution: water for injection.

Indications for use

• Allergic reactions, including hay fever, urticaria, angioedema;
• Hemorrhagic vasculitis;
• allergic conjunctivitis;
• serum sickness;
• Chorea;
• Vasomotor rhinitis;
• Itchy dermatoses;
• Sleep disorders, as monotherapy or in combination with sleeping pills;
• Vomiting of pregnant women;
• Air and sea sickness;
• Meniere's syndrome;
• Premedication.

Contraindications

• Stenosing ulcer of the duodenum and / or stomach;
• Bronchial asthma;
• Angle-closure glaucoma;
• Stenosis of the neck of the bladder;
• prostatic hypertrophy;
• Epilepsy;
• Hypersensitivity to diphenhydramine.

With caution and according to strict indications, diphenhydramine is prescribed during pregnancy and during breastfeeding, only if the expected benefit to the mother outweighs the likely risk to the fetus or child.

Method of application and dosage

• Tablets: taken orally. Dosage for adult patients: as a sleeping pill - 50 mg at bedtime; treatment - 30-50 mg 1-3 times a day, for 10-15 days. For children, a single dose is: under the age of 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; from 6 to 12 years - 15-30 mg;
• Solution for intravenous and intramuscular administration: for adult patients, intramuscular injections at a dose of 50 to 250 mg, intravenous drip - 20-50 mg. Outwardly it is recommended to apply 1-2 times a day.

Side effects

The use of Dimedrol can cause side effects:

• Perhaps: drowsiness, short-term numbness of the oral mucosa, decreased attention, general weakness; in children - the paradoxical development of insomnia, euphoria and irritability;
• Rarely: headache, dizziness, incoordination, nausea, dry mouth, photosensitivity, tremor, accommodation paresis.

special instructions

During pregnancy and breastfeeding, the drug should be used under close medical supervision.

It is prescribed with caution to patients engaged in potentially hazardous types of work, the implementation of which requires rapid psychomotor reactions and increased attention.

drug interaction

The use of Dimedrol increases the activity of drugs that depress the central nervous system, enhances the effect of ethanol.

The combination with monoamine oxidase (MAO) inhibitors increases the anticholinergic activity of the drug.

Antagonistic reaction occurs against the background of a joint appointment with psychostimulants.

Simultaneous use of the drug reduces the emetic effect of apomorphine in the treatment of poisoning.

The drug increases the anticholinergic effects of drugs with anticholinergic activity.

Analogues

Analogues of Dimedrol are: Dimedrol-ROS, Dimedrol-UBF, Dimedrol-UVI, Dimedrol-Vial, Dimedrol Bufus, Dramina, Kalmaben.

Terms and conditions of storage

• Tablets: store in a dry, dark place;
• Solution: store in a place protected from light at temperatures up to 30 ° C.

Keep away from children.

Shelf life - 5 years.

It has antihistamine, antiallergic, antiemetic, hypnotic, local anesthetic effect. Blocks histamine H 1 - receptors and eliminates the effects of histamine mediated through this type of receptor. Reduces or prevents histamine-induced spasms of smooth muscles, increased capillary permeability, tissue swelling, itching and hyperemia. Antagonism with histamine manifests itself to a greater extent in relation to local vascular reactions during inflammation and allergy compared to systemic ones, i.e. lowering BP. It causes local anesthesia (when taken orally, there is a short-term sensation of numbness of the oral mucosa), has an antispasmodic effect, blocks the cholinergic receptors of the autonomic ganglia (lowers blood pressure). Blocks H 3 - histamine receptors in the brain and inhibits the central cholinergic structures. It has a sedative, hypnotic and antiemetic effect. It is more effective in bronchospasm caused by histamine liberators (tubocurarine, morphine, sombrevin), to a lesser extent - in allergic bronchospasm. In bronchial asthma, it is inactive and is used in combination with theophylline, ephedrine and other bronchodilators.

Pharmacokinetics

When taken orally, it is rapidly and well absorbed. Contacts proteins of plasma for 98 — 99%. The maximum concentration (Cmax) in plasma is reached 1-4 hours after ingestion. Most of the accepted diphenhydramine is metabolized in the liver. The half-life (T 1/2) is 1-4 hours. It is widely distributed in the body, passes through the blood-brain barrier and the placenta. Excreted in milk and may cause sedation in infants. During the day, it is completely excreted from the body mainly in the form of benzhydrol conjugated with glucuronic acid, and only in a small amount - unchanged. The maximum effect develops 1 hour after ingestion, the duration of action is from 4 to 6 hours.

Indications for use

Urticaria, hay fever, vasomotor rhinitis, itchy dermatoses, acute iridocyclitis, allergic conjunctivitis, angioedema, capillarotoxicosis, serum sickness, allergic complications during drug therapy, blood transfusion and blood-substituting fluids; complex therapy of anaphylactic shock, radiation sickness, bronchial asthma, peptic ulcer stomach and hyperacid gastritis; colds, sleep disturbances, premedication, extensive injuries of the skin and soft tissues (burns, crush injuries); parkinsonism, chorea, sea and air sickness, vomiting, Meniere's syndrome; local anesthesia in patients with a history of allergic reactions to local anesthetic drugs.

Contraindications

Hypersensitivity, breast-feeding, childhood (newborn period and prematurity), angle-closure glaucoma, prostatic hypertrophy, stenosing gastric and duodenal ulcer, pyloroduodenal obstruction, bladder neck stenosis, pregnancy, bronchial asthma.

Dosage and administration

The drug is taken orally. Adults are prescribed 30-50 mg 1-3 times a day, the course of treatment is 10-15 days. To prevent motion sickness, you should take a single dose of 30-50 mg 30-60 minutes before the trip; with insomnia - 30-50 mg at bedtime. The maximum single dose is 100 mg, daily - 250 mg. Children aged 6-12 years are prescribed 15-30 mg per dose.

Side effect

From the nervous system and sensory organs: general weakness, fatigue, sedation, decreased attention, dizziness, drowsiness, headache, impaired coordination of movements, anxiety, irritability (especially in children), irritability, nervousness, insomnia, euphoria, confusion , tremor, neuritis, convulsions, paresthesia; blurred vision, diplopia, acute labyrinthitis, tinnitus. In patients with local brain damage or epilepsy, it activates (even at low doses) convulsive discharges on the EEG and can provoke an epileptic seizure.

From the side of the cardiovascular system and blood: hypotension, palpitations, tachycardia, extrasystole, agranulocytosis, thrombocytopenia, hemolytic anemia.

From the digestive tract: dry mouth, short-term numbness of the oral mucosa, anorexia, nausea, epigastric distress, vomiting, diarrhea, constipation.

From the genitourinary system: frequent and / or difficult urination, urinary retention, early menstruation.

From the respiratory system: dryness of the nose and throat, nasal congestion, thickening of bronchial secretions, tightness in the chest and shortness of breath.

Allergic reactions: rash, urticaria, anaphylactic shock.

Other: sweating, chills, photosensitivity.

One tablet contains

active substance - diphenhydramine hydrochloride 50.0 mg,

excipients: lactose monohydrate, potato starch, anhydrous colloidal silicon dioxide (aerosil), stearic acid.

Description

Tablets are white or almost white, with a flat surface. On one side of the tablet there is a chamfer, on the other - a chamfer and a company logo in the form of a cross.

Pharmacotherapeutic group

Systemic antihistamines. Aminoalkyl ethers. Diphenhydramine

ATX code R06AA02

pharmachologic effect

Pharmacokinetics

When taken orally, the drug is rapidly absorbed from the gastrointestinal tract. The maximum concentration in blood plasma is reached after 1-4 hours. Communication with blood plasma proteins is 98-99%. Penetrates through the blood-brain and placental barriers. Metabolized in the liver.

Excreted by the kidneys during the day in the form of inactive metabolites conjugated with glucuronic acid.

The half-life (T1 / 2) is from 1 to 10 hours.

The maximum effect develops 20 minutes after ingestion, the duration of action is 4-6 hours.

Pharmacodynamics Antihistamine, antiemetic, sedative and hypnotic. It is a blocker - H1 - histamine receptors. The antihistamine effect is due to the elimination of spasm, congestion (tissue edema) due to competition with H1-histamine receptors on effector cells, preventing, but not changing the histamine-mediated response.

The antiemetic effect is due to inhibition of the brain chemoreceptor trigger zone.

It helps to reduce dizziness due to the central m-anticholinergic effect on the vestibular apparatus, the integrative vomiting center and the brain chemoreceptor of the trigger zone of the medulla oblongata.

The exact mechanism of action of CNS depression is unknown. Perhaps the reason is the indirect inhibition of impulses in the reticular formation.

Indications for use

As an antihistamine:

With allergic conjunctivitis on the background of food allergies,

With mild, uncomplicated skin allergic reactions with urticaria and angioedema,

To reduce the intensity of allergic reactions in the blood or serum

With dermatographism

For the treatment of anaphylactic reactions in complex therapy with epineforin and other measures after the relief of an acute condition.

As a prophylactic and therapeutic agent for air and sea sickness.

As an antiparkinsonian agent.

For the treatment of parkinsonism (including drug-induced) in the elderly with the inability to use potent drugs; mild course of parkinsonism (including drug-induced) in other age groups, parkinsonism (including drug-induced) in combination with anticholinergics of central action.

For the symptomatic treatment of temporary sleep disorders.

Dosage and administration

Use the drug inside, as prescribed by the doctor.

Adults: 25-50 mg (½ - 1 tablet) 3-4 times a day.

For temporary sleep disturbance (insomnia) for adults and children over 16 years of age: 50 mg (1 tablet) 20 minutes before bedtime.

To prevent motion sickness, first take ½ - 1 tablet 30 minutes before the trip, then the same dose before meals and before the end of the trip.

Maximum doses for adults: single - 100 mg, daily - 250 mg.

Children over 6 years old: 12.5-25 mg (1/4 - ½ tablet) 3-4 times a day.

The maximum daily dose should not exceed 300 mg.

Do not use as a sleeping pill for children under 12 years of age!

Course of treatment: 3-5 days, the question of a longer treatment is decided by the attending physician.

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Side effects

Often (> 1/100 to<1/10)

General weakness, drowsiness, impaired attention, unsteadiness

Dry mouth

unknown

Skin rash, urticaria, anaphylactic shock

angioedema

Confusion, paradoxical agitation (eg, restlessness, nervousness) especially in the elderly

patients

Seizures, paresthesias, dyskinesias

Headache

Blurred vision

Noise in ears

Tachycardia

Thickening of bronchial secretions, nasal congestion, tightness in the chest

Gastrointestinal disorders such as nausea, vomiting, anorexia, constipation

Difficulty, frequent urination, urinary retention

Agranulocytosis, thrombocytopenia, hemolytic anemia

Sweating, chills, photosensitivity

Contraindications

Hypersensitivity to active or any of

drug excipients

Angle-closure glaucoma

prostatic hypertrophy

Stenosing ulcer of the stomach and duodenum

Bladder neck stenosis

Bronchial asthma

Epilepsy

Pregnancy and lactation

Children's age up to 6 years

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Drug Interactions

With the simultaneous use of diphenhydramine enhances the sedative effect of ethanol and other drugs that depress the central nervous system (for example, tranquilizers, hypnotics).

With simultaneous use with monoamine oxidase inhibitors, the anticholinergic activity of diphenhydramine is enhanced and lengthened. The drug should not be combined with MAO inhibitors, it is recommended to prescribe diphenhydramine 2 weeks after stopping their intake.

Antagonistic interaction is noted when co-administered with psychostimulants. Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Enhances the anticholinergic effects of drugs with anticholinergic activity (for example, atropine, tricyclic antidepressants).

special instructions

During treatment it is necessary to avoid the use of alcohol.

The drug should be used with caution in the elderly, due to the presence of a higher risk of side effects.

Diphenhydramine should be prescribed with caution to patients with liver disease and moderate and severe renal dysfunction, myasthenia gravis, chronic obstructive pulmonary disease, bronchitis.

The drug may aggravate already existing tinnitus in patients with this symptom.

With prolonged use of the drug, the development of drug dependence is possible.

Due to the fact that the drug contains lactose monohydrate, it is not recommended to prescribe it to patients with rare hereditary diseases such as galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.

Application in pediatrics

Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

The active substance of the drug Diphenhydramine, diphenhydramine, belongs to H1 receptor blockers. By blocking the addition of histamine, it helps to relax smooth muscle fibers, improve the functioning of the autonomic nerve plexuses and trunks. It is widely used in allergology for the treatment of skin manifestations of allergies. In neurological and ENT practice, it has found its application in the treatment of diseases accompanied by the development of dizziness and hyperkinetic disorders (Ménière's disease, Parkinson's disease or Parkinson's syndrome). It is well tolerated by patients, does not accumulate in tissues and does not cause side effects.

1. Pharmacological action

Drug group:

Antihistamine.

Therapeutic effects of Dimedrol:

• Antihistamine;
• Antiemetic;
• Antiallergic;
• Hypnotic;
• Sedative;
• Local anesthetic.

Peculiarities:

• Able to pass through the placental and blood-brain barriers;
• Widely distributed throughout the body and excreted in breast milk;
• The maximum effect of the drug develops after 1 hour and lasts for 4-6 hours.

Binding to plasma proteins: 98-99%.

2. indications for use

The drug is used for:

• Complex treatment of radiation sickness, gastric ulcer, bronchial asthma, hyperacid;
• Treatment of vasomotor, acute iridocyclitis, angioedema, serum sickness, hay fever, pruritic dermatoses, allergic, capillary toxicosis, various allergic complications, sleep disturbances, extensive injuries of the skin and soft tissues, chorea, vomiting, colds, parkinsonism, air and / or sea disease, Meniere's syndrome;
• Premedication, local anesthesia in patients with hypersensitivity to local anesthetics.

3. How to use

Recommended dosage of Diphenhydramine in tablet form:

Insomnia:

50 mg half an hour before going to bed;

Postencephalic or idiopathic parkinsonism:

25 mg 3 times a day with a gradual increase in dosage to 50 mg 4 times a day;

Motion sickness:

25-50 mg every 4-6 hours if necessary;

Children 2-6 years old:

12.5-25 mg;

Children 6-12 years old:

25-50 mg every 6-8 hours;

Children over 12 and adults:

30-50 mg 1-3 times a day.

Recommended dosage of the drug in parenteral form:

Intramuscularly:

50-250 mg;

Intravenous drip:

25-50 mg, dissolved in 75-100 ml of saline.

Children under 3 years old:

Children 3-4 years old:

Children 5-7 years old:

1-2 drops of 0.2-0.5% solution in the conjunctival sac 2-5 times a day;

Intranasally:

1 stick in each nostril;

Preparation in the form of a gel:

Apply a thin layer on the affected areas of the skin several times a day.

Application Features:

• According to the instructions, exceeding the dosage of the drug is not permissible, in order to avoid the occurrence of undesirable effects.

4. Side effects

Nervous system:

fatigue, decreased attention, drowsiness, drowsiness, impaired coordination of movements, irritability, nervousness, euphoria, convulsions, paresthesia, provocation of an epileptic attack, general weakness, sedative effect, dizziness, headaches, anxiety, irritability, insomnia, confusion, neuritis;

Respiratory system:

nasal congestion, tightness in the chest, dry nose and throat, thickening of bronchial secretions, difficulty breathing;

The cardiovascular system:

Digestive system:

short-term numbness of the oral mucosa, nausea, vomiting, constipation or dry mouth, anorexia, epigastric distress;

Urinary system:

urinary retention, frequent and / or difficult urination;

Reproductive system:

early menstruation;

Blood system:

decrease in the number of granulocytes and platelets,;

Sense organs:

diplopia, tinnitus, visual impairment, acute labyrinthitis;

Skin lesions:

photosensitivity;

chills, sweating.

5. Contraindications

6. During pregnancy and lactation

Pregnant women and nursing mothers should use the drug categorically contraindicated.

7. Interaction with other drugs

Simultaneous use of Dimedrol with:

Tranquilizers, sleeping pills, sedatives or alcohol-containing drugs:

improving their efficiency.

8. Overdose

Symptoms:

Nervous system:

depression or excitation (more often in children) of the central nervous system, convulsions, confusion, death;

Respiratory system:

labored breathing;

The cardiovascular system:

redness of the face;

Digestive system:

dry mouth.

Specific antidote: no data available.

Treatment of overdose with Diphenhydramine:

• Gastric lavage in the first few hours;
• Reception of activated carbon or other sorbent drugs in the maximum possible dosage;
• Maintaining vital signs within normal limits;
• symptomatic treatment.

Hemodialysis: no data.

9. Release form

• Coated tablets, 50 mg - 10, 20, 30, 1500, 1600 or 4000 pcs.
• Solution for injection, 10 mg / 1 ml - amp. 10 pieces.

10. Storage conditions

• Being in the original packaging or tightly closed container;
• Dry dark place out of reach of children, sunlight and heat sources.

Different, depending on the dosage form and the manufacturer, is indicated on the package.

11. Composition

1 tablet:

• diphenhydramine - 50 mg.

1 ml solution:

• diphenhydramine - 10 mg.

12. Terms of dispensing from pharmacies

The drug is released according to the prescription of the attending physician.

How to breed Diphenhydramine with Analgin

In case of severe fever and pain, the combination of Diphenhydramine and Analgin effectively helps. Instructions for use Dimedrol says that the drug is an antiallergic agent that eliminates allergies, relieves swelling. Analgin is a non-steroidal anti-inflammatory drug that relieves pain, fever and inflammation. In combination, these agents are most effective, so they are often used in one syringe.

This combination has an effect after 15 minutes and lasts for about 6 hours. It is better for children to use Diphenhydramine with Analgin in the form of suppositories, which are called Analdim, but, in extreme cases, injections are also used.

For children, the dosage of Analgin with Diphenhydramine is calculated depending on weight and age. For adults weighing about 60 kg, 2 ml of Analgin and 1 ml of Dimedrol are used.

These are only approximate dosages, the exact amount of the drug is determined only by the doctor.!

The drugs are collected in 1 syringe. First Analgin, then Dimedrol. In this case, the drugs do not mix. This mixture should be administered slowly and intramuscularly.

Is it possible Diphenhydramine with alcohol

Combining Diphenhydramine with alcoholic beverages is dangerous not only for health, but also for life. The drug enhances the effect of alcohol, which can even lead to death.

In addition to severe intoxication, the liver, kidneys, organs of the gastrointestinal tract, heart and nervous system begin to suffer. Alcohol in combination with Diphenhydramine can lead to hallucinations and change a person beyond recognition.

It is not known exactly what consequences such a combination will lead to, therefore it is strictly forbidden to take Diphenhydramine with alcohol.

Analgin, Diphenhydramine and Papaverine in one syringe

The combination of drugs such as DimedroI, Analgin and Papaverine is very often used in one syringe. This combination is used in surgery, gynecology, urology, therapy and other fields..

The lytic mixture is used to relieve fever, pain and spasm. Analgin has an analgesic and antipyretic effect. Papaverine relieves muscle spasms and dilates blood vessels. Diphenhydramine is able to eliminate allergic manifestations, and also has a sedative effect.

To obtain a lytic mixture, 2 ml of 50% Analgin, 1 ml of 1% Diphenhydramine and 2 ml of 2% Papaverine are collected in one syringe for adults. This combination is administered intramuscularly and slowly.

For children, the dosage of the mixture is calculated depending on weight and age.

But it should be remembered that it is dangerous to use such a combination on your own, because the drugs have a number of side effects and contraindications.

Diphenhydramine for insomnia

Diphenhydramine is an antihistamine drug, but due to its sedative effect, it is often used for insomnia. At the same time, the instructions noted that a sedative and hypnotic effect occurs when the drug is taken again.

The doctor prescribes the exact dosage and duration of treatment, on average, for insomnia, 50 mg of the drug will be used half an hour before bedtime.

Diphenhydramine has a number of side effects and contraindications, and in case of an overdose it leads to undesirable consequences, therefore, it is strictly forbidden to prescribe the drug yourself as a sleeping pill. Especially since medicine dispensed by prescription.

Diphenhydramine for toothache and headache

In the instructions for Dimedrol, among the therapeutic effects, you can see that the drug causes local anesthesia. Namely, when taken orally, a short-term numbness of the oral mucosa occurs. But can Diphenhydramine be used for toothache, as well as headaches?

Diphenhydramine is usually used for toothache, in the absence of other painkillers before visiting the dentist. To do this, a quarter or half of the tablet is placed on the aching tooth and wait for the onset of the therapeutic effect. And also the drug can be ground into powder and applied to the gum of the disturbing tooth.

It should be borne in mind that the drug causes drowsiness and reduces concentration, so it is preferable to use it before bedtime, and go to the dentist in the morning.

With intense headache and toothache, Analgin and Dimedrol combinations are used once, 1 tablet each, or as intramuscular injections in one syringe.

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* Instructions for medical use for the drug Dimedrol published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, IT IS NECESSARY TO CONSULT WITH A SPECIALIST

Indications for use:
Urticaria, hay fever, vasomotor rhinitis, itchy dermatoses, acute iridocyclitis, allergic conjunctivitis, angioedema, capillarotoxicosis, serum sickness, allergic complications during drug therapy, blood transfusion and blood-substituting fluids; complex therapy of anaphylactic shock, radiation sickness, bronchial asthma, gastric ulcer and hyperacid gastritis; colds, sleep disturbances, premedication, extensive injuries of the skin and soft tissues (burns, crush injuries); parkinsonism, chorea, sea and air sickness, vomiting, Meniere's syndrome; local anesthesia in patients with a history of allergic reactions to local anesthetic products.

Pharmachologic effect:
It has antihistamine, antiallergic, antiemetic, hypnotic, local anesthetic effect. It blocks histamine H1 receptors and eliminates the effects of histamine mediated through this type of receptor. Reduces or prevents histamine-induced spasms of smooth muscles, increased capillary permeability, tissue swelling, itching and hyperemia. Antagonism with histamine manifests itself to a greater extent in relation to local vascular reactions during inflammation and allergy compared to systemic ones, i.e. lowering BP. It causes local anesthesia (when taken orally, there is a short-term sensation of numbness of the oral mucosa), has an antispasmodic effect, blocks the cholinergic receptors of the autonomic ganglia (lowers blood pressure). Blocks H3 - histamine receptors in the brain and inhibits the central cholinergic structures. It has a sedative, hypnotic and antiemetic effect. It is more effective in bronchospasm caused by histamine liberators (tubocurarine, morphine, sombrevin), to a lesser extent - in allergic bronchospasm. In bronchial asthma, it is inactive and is used in combination with theophylline, ephedrine and other bronchodilators.

Pharmacokinetics:
When taken orally, it is rapidly and well absorbed. Contacts proteins of plasma for 98-99%. The maximum concentration (Cmax) in plasma is reached after 1-4 hours after ingestion. Most of the accepted diphenhydramine is metabolized in the liver. The half-life (T1 / 2) is 1-4 hours. It is widely distributed in the body, passes through the blood-brain barrier and the placenta. Excreted in milk and may cause sedation in infants. During the day, it is completely excreted from the body mainly in the form of benzhydrol conjugated with glucuronic acid, and only in a non-cordial amount - unchanged. The maximum effect develops after 1 hour after ingestion, the duration of action is from 4 to 6 hours.

Diphenhydramine method of administration and dose:
inside. Adults, 30-50 mg 1-3 times daily. The course of treatment is 10-15 days. Higher doses for adults: single - 100 mg, daily - 250 mg. With insomnia - 50 mg 20-30 minutes before bedtime. For the treatment of idiopathic and postencephalitic parkinsonism - initially 25 mg 3 times every day, followed by a gradual increase in dose, if required, up to 50 mg 4 times a day. When motion sickness - 25-50 mg every 4-6 hours if necessary. Children 2-6 years old - 12.5-25 mg each, 6-12 years old - 25-50 mg every 6-8 hours (no more than 75 mg / day for babies 2-6 years old and no more than 150 mg / day for babies 6 -12 years). V / m, 50-250 mg; the highest single dose - 50 mg, daily - 150 mg. In / in drip - 20-50 mg (in 75-100 ml of 0.9% NaCl solution). Rectally. Suppositories are administered 1-2 times a day after a cleansing enema or spontaneous bowel movement. Children under 3 years old - 5 mg, 3-4 years old - 10 mg; 5-7 years - 15 mg, 8-14 years - 20 mg. In ophthalmology: 1-2 drops of 0.2-0.5% solution are instilled into the conjunctival sac 2-3-5 times a day. Intranasally. With allergic vasomotor, acute rhinitis, rhinosinusopathy, it is prescribed in the form of sticks containing 0.05 g of diphenhydramine.

Diphenhydramine gel is used externally. Apply a thin layer to the affected areas of the skin several times every day.

Diphenhydramine contraindications:
Hypersusceptibility, breastfeeding, childhood (newborn period and prematurity), angle-closure glaucoma, prostatic hypertrophy, stenosing gastric and duodenal ulcer, pyloroduodenal obstruction, bladder neck stenosis, pregnancy, bronchial asthma.

Use with other medicinal products:
Sleeping pills, sedatives, tranquilizers and alcohol increase (mutually) CNS depression. MAO inhibitors enhance and prolong anticholinergic effects.

Overdose:
Symptoms: dry mouth, shortness of breath, persistent mydriasis, redness of the face, depression or excitement (more often in babies) of the central nervous system, confusion; in babies - the development of seizures and death.
Treatment: induction of vomiting, gastric lavage, administration of activated charcoal; symptomatic and supportive therapy against the background of careful monitoring of breathing and blood pressure levels.

Special instructions:
Use with caution in patients with hyperthyroidism, increased intraocular pressure, diseases of the cardiovascular system, in old age. It should not be used during work by drivers of vehicles and people whose profession is associated with increased concentration of attention. During the period of treatment should avoid the use of alcoholic beverages.

Diphenhydramine side effects:
From the nervous system and sensory organs: general weakness, fatigue, sedation, decreased attention, dizziness, drowsiness, headache, impaired coordination of movements, anxiety, high excitability (especially in babies), irritability, nervousness, insomnia, euphoria, confusion , tremor, neuritis, convulsions, paresthesia; blurred vision, diplopia, acute labyrinthitis, tinnitus. In patients with local brain damage or epilepsy, it activates (even at low doses) convulsive discharges on the EEG and can provoke an epileptic seizure.

From the side of the cardiovascular system and blood: hypotension, palpitations, tachycardia, extrasystole, agranulocytosis, thrombocytopenia, hemolytic anemia.

From the digestive tract: dry mouth, short-term numbness of the oral mucosa, anorexia, nausea, epigastric distress, vomiting, diarrhea, constipation.

From the genitourinary system: frequent and / or difficult urination, urinary retention, early menstruation.

From the respiratory system: dryness of the nose and throat, nasal congestion, thickening of bronchial secretions, tightness in the chest and shortness of breath.

Allergic reactions: rash, urticaria, anaphylactic shock.

Other: sweating, chills, photosensitivity.

Release form:
There are such forms of release of Dimedrol:
Powder; tablets of 0.02; 0.03 and 0.05 g; suppositories with diphenhydramine 0.005 each; 0.001; 0.015 and 0.02 g; sticks with diphenhydramine 0.05 g; 1% solution in ampoules and syringe tubes. Candles with diphenhydramine are intended for use in pediatric practice. Gel for external use, pencils.

Synonyms:
Diphenhydramine hydrochloride, Diphenhydramine, Allergan B, Benadryl, Benzhydramine, Alledryl, Allergival, Amidryl, Diabenil, Dimedryl, Dimidryl, Restamin.

Storage conditions:
List B. In a well-closed container, protected from light and moisture; tablets and ampoules - in a place protected from light; candles - in a dry, cool, dark place.

Dimedrol composition:
White fine-crystalline powder of bitter taste; causes numbness of the tongue. Hygroscopic. Easily soluble in water, very easily in alcohol. Aqueous solutions (pH 1% solution 5.0 - 6.5) are sterilized at +100 ° C for 30 minutes.

Attention!
Before using the medication "Dimedrol" you need to consult a doctor.
The instructions are provided solely for familiarization with " Diphenhydramine».